Genetic susceptibility to juvenile idiopathic arthritis in Iranian children
نویسندگان
چکیده
منابع مشابه
Genetic susceptibility to juvenile idiopathic arthritis in Iranian children
BACKGROUND AND AIMS This study was comprised of Iranian children with oligoarthritis and rheumatoid factor negative (RF) polyarthritis subtypes of juvenile idiopathic arthritis (JIA) to determine the association of HLA-DRB1 alleles in Iran. METHODS HLA-DRB1 alleles were investigated in 33 Iranian children with oligoarthritis and RF negative polyarthritis JIA and compared with 45 healthy contr...
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Juvenile idiopathic arthritis (JIA) is a multifactorial disease with a pathogenesis which remains inexplicable. However, genome-wide association studies brought forward within recent years have discovered several new susceptibility genes, and accumulating evidence supports genetic variability as playing a key role in JIA development. This review summarises the present knowledge of human leukocy...
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OBJECTIVE To investigate whether single-nucleotide polymorphisms (SNPs) within the genes PRF1, GZMB, UNC13D, and Rab27a, which are involved in natural killer cell dysfunction and known to contribute to the risk of hemophagocytic lymphohistiocytosis (HLH), confer an increased risk of susceptibility to systemic-onset juvenile idiopathic arthritis (JIA). METHODS Four SNPs across the PRF1 gene lo...
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ژورنال
عنوان ژورنال: Pediatric Rheumatology
سال: 2011
ISSN: 1546-0096
DOI: 10.1186/1546-0096-9-s1-p103